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Parkinson’s disease mechanisms and non-motor symptoms: Novel investigate strategies

 Professor Poul Henning Jensen from Department of Biomedicine, Aarhus University of Denmark had a lecture on “Parkinson’s disease mechanisms and non-motor symptoms. Novel investigate strategies” on 10 March 2019 at NIGEB. He explained that Parkinson`s disease belongs to the group of late-onset neurodegenerative diseases where a prion-like spreading of a protein aggregate composed of a-synuclein is hypothesized to seed the subsequent aggregation of native a-syncuclein in recipient neurons and will cause a progressive build-up of aggregates that ultimately may kill the cell.

However, the rate of the build-up will depend on the cell`s homeostatic mechanisms like chaperones and autophagy and may take many years. During this period, the neurons encounter the effects of the progressive accumulation of aggregates and this may affect different aspects of its functionality, e.g. electrophysiological properties, and thereby contribute to some of the non-motor symptoms encountered by the patients.