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Institute of Medical Biotechnology

 

Institute of Medical Biotechnology

 

Director: Dr.Alireza Zomorodipour (zomorodi@nigeb.ac.ir)

 

The IMB was launched in March 2014 by merging three active research departments of the NIGEB, (i.e. Medical Genetics Department, Basic Sciences Department and Stem Cell Department). The IMB has 26 full-time faculty members, including 1 full professor, 6 associate professors, 19 assistant professors and 5 research assistants.

 

The research departments of the IMB include:

·         Medical Genetics

·         Molecular Genetics

·         Stem Cell and Regenerative Medicine

 

The faculty members of the IMB contribute to pave the way to solve the problems and meet the needs of the country through implementing the mission-oriented projects in the area of cancer, genetics of multiple sclerosis (MS), stem cell and various research projects in the area of medical biotechnology. The IMB provides training opportunities to the guest students of other Iranian universities in the framework of internship or conducting M.Sc. theses and Ph.D. dissertations.

Besides, the IMB independently provides education opportunities in medical biotechnology areas.

Departments

 

1.    Medical Genetics Department

 

Head: Dr. Mehdi Sadeghi

 

Research Interests

*      Genetics of Multiple Sclerosis (MS)

*      Study of Genetic Mitochondrial Diseases

*      Study of Molecular Pathology of Genetic-Based Immune Diseases

*      Molecular and Genetic Diagnosis of Cancer

*      Chromosomal Abnormality in Human Disease

*      Neuro-ImmunoOnco Psychogenetic Studies

*      Bioinformatics and Modeling

*      Diagnosis of Genetic Diseases (single-gene and multi-factorial disorders)

*      MicroRNA  and Gene Expression Profiling

*      Novel Therapeutic Approaches for Cancer and Autoimmune Diseases

*      Genetics of Hyperthyroidism

*      Cardiovascular and Diabetes Treatment Studies

*      Pharmacogenetics

*      Application of FISH Technique in Cancer

 

2.    Molecular Medicine Department

 

Head: Dr. Azita Parvaneh Tafreshi

 

Research Interests

*      Molecular Mechanisms and Cell Signaling pathways in Cancer and Neurodegenerative Disease

*      Isolation and Study of Anti-cancer and Anti-inflammatory Compounds from Iranian Folk Plants

*      Differentiation-Therapy Approaches in Cancer

*      Application of Nanophotocatalysts and the Role of Genes in Photodynamic Therapy of Cancer

*      Non-coding RNAs and Epigenetic Regulation of Gene Expression

*      Gene Expression Patterns in Cancer and Development of Diagnostic Kits

*       Roles of miRNAs in Development and Human Diseases

*      Neuroinflammatory Factors and Cell Therapy in Neuronal Damage Diseases

*      Establishment of Drug Delivery Systems and Nanobiopharmaceutics

*      Gene Transfer Systems Based on AAV and Lentiviral Vectors

*      Novel strategies in Production of Recombinant Medicinal Proteins

*      Study the Mechanisms of Angiogenesis and Plant-derived antiangiogenic Inhibitors

*      Production of an Angiogenesis Inhibitor for Gene Therapy of Cancer, Blindness and Metastasis 

*      Molecular Mechanisms and Cell Signaling Pathways in Stem Cell Differentiation toward Neural Cells

*      Molecular Mechanisms and Cell Signaling Pathways in Neuroglial Cells  Using Blocks and Inducers of Defined Pathway

*      Evaluation of Therapeutic Strategies in Animal Models of Multiple Sclerosis (MS)

*      Mechanisms of Toxins Secreted from Colonized Bacteria in Large Intestine in Colorectal Cancer

*      The Role of Apoptosis and Autophagy in Cancer Modulation

*      Gene Expression Profiling in Cancer

*      Living Organisms' Natural Products  as Valuable Sources of Anti-cancer Drugs

*      Gene-expression Tools for Metabolic Engineering of Diseases

*      Cell Replacement Therapy in Neurodegenerative Disease

 

 

 

 

3.    Stem Cell and Regenerative Medicine Department

 

Head: Dr. Maryam Kabir Salmani

 

Research Interests

*      Spermatogonial  Stem Cells and Fertility

*      Characterization of in vivo/in vitro Models for Cancer Stem Cells

*      Genomic-free Induced Pluripotency and their Differentiation

*      Cardiac/Neural Differentiation of Adipose Tissue Stem Cells

*      Production of Chimeric Antibodies

*      Fabrication of Deep Brain Implantable Scaffold for Parkinson Disease Treatment using Engineered Mesenchymal Stem Cells

*      Fabrication and Characterization of Bulk Metallic Glasses ( BMGs) for Biomedical Applications

*      Nanostructured Platforms for Gene/Protein Therapy and Tissue Engineering

 

 

Human Resources

Full Professors: 1

 Associate Professors: 6

 Assistant Professors: 19

 

Research Assistants: 5

Post-graduate Students (M.Sc. and Ph.D.): 62

Guest Students (M.Sc. and Ph.D.): 32

 

Mission

Regarding the fact that cancer is among the leading causes of death in Iran and in the world, and due to the fact that the statistics prognosticate its growing rates for the developing countries in the coming years, the main mission of the IMB has focused on the development of new methods for diagnosis and treatment of cancer through:

 

Cancer genetics studies for technical knowledge and rapid detection

Genomics studies for developing the knowledge on cancer pathogens

Personalized medicine against cancers

Application of stem cells in cancer therapy

Cancer gene therapy